Kugereranya uburyo bubiri bwo gutahura uburyo bwo kumenya SARS-CoV-2 reseptor ihuza indangarugero IgG antibody nkikimenyetso cya surrogate cyo gusuzuma antibodiyite zangiza abarwayi ba COVID-19

Int J Yanduye.Ku ya 20 Kamena 2021: S1201-9712 ​​(21) 00520-8.doi: 10.1016 / j.ijid.2021.06.031.Kumurongo mbere yo gucapa.
Amavu n'amavuko: Kutabogama antibodiyite (NAbs) ni ngombwa kugirango wirinde kwanduzwa na COVID-19.Twagereranije ibizamini bibiri bifitanye isano na NAb, aribyo ikizamini cya hemagglutination (HAT) n'ikizamini cyo gusimbuza virusi (sVNT).
Uburyo: Umwihariko wa HAT wagereranijwe na sVNT, kandi isuzumabushobozi hamwe nigihe kirekire cya antibodi ku barwayi bafite uburwayi butandukanye bwasuzumwe mu itsinda ry’abarwayi 71 mu byumweru 4 kugeza kuri 6 n'ibyumweru 13 kugeza 16.Isuzuma rya kinetic y’abarwayi bafite uburwayi bukabije bwuburemere butandukanye ryakozwe mu cyumweru cya mbere, icya kabiri n'icya gatatu.
Ibisubizo: Umwihariko wa HAT ni> 99%, kandi ibyiyumvo bisa nibya sVNT, ariko biri munsi yubwa sVNT.Urwego rwa HAT rufitanye isano cyane nurwego rwa sVNT (r = 0,78, Icumu, p <0.0001).Ugereranije n’abarwayi bafite uburwayi bworoheje, abarwayi bafite uburwayi buciriritse kandi bukabije bafite titeri nyinshi za HAT.6/7 abarwayi barembye cyane bari bafite titer ya> 1: 640 mucyumweru cya kabiri cyatangiye, mugihe abarwayi 5/31 gusa barwaye byoroheje bafite titer ya> 1: 160 mucyumweru cya kabiri cyo gutangira.
Umwanzuro: Kubera ko HAT ari uburyo bworoshye kandi buhendutse bwo gutahura, nibyiza nkikimenyetso cya NAb mubutunzi-bubi.