Vanessa Chen

Jiangsu Konsung Bio-Medical Science and Technology Co., Ltd. Nanjing 210012, Jiangsu, mu Bushinwa

Incamake: Kubura amaraso, indwara ikunze kugaragara ku isi yose, bigira ingaruka zikomeye ku buzima n'imibereho myiza y'abantu babarirwa muri za miriyoni amagana. Gupima hakiri kare ni ingenzi cyane mu kunoza imiterere y'indwara z'abarwayi no kugabanya umutwaro w'indwara. Kubera ko ibikoresho by'ubuvuzi birimo kugabanuka bikagera ku rwego rwo hasi, ni ngombwa gushyiraho ibikoresho byo gupima neza kandi byoroshye. Iyi nkuru ifata Konsung Hemoglobin Analyzer (H7 series) nk'ikintu cy'ubushakashatsi kandi ikagenzura agaciro k'ikoreshwa ry'ihame ryayo ryo gupima amaraso mu gusuzuma amaraso. Binyuze mu isesengura ryakozwe ku bipimo by'imikorere y'ibikoresho, amakuru menshi yo kwemeza indwara, no kugereranya n'uburyo gakondo bwo gupima muri laboratwari, byagaragaye ko igikoresho cyagaragaje ubuhanga bwo hejuru (± 2% by'amakosa) n'ubushobozi bwo hejuru (amasegonda 3/icyitegererezo) mu gupima hemoglobin. Imiterere yacyo ishobora kwimurwa no gukora byoroshye byagabanyije cyane urugero rw'abakozi b'abaganga ba mbere rwo kugikoresha. Cyane cyane cyane mu gupima ku rwego runini mu bigo by'ubuvuzi by'ibanze. Ubushakashatsi bwagaragaje kandi ko iki gikoresho gifite igipimo cya mbere cyo gusuzuma neza ikibazo cy’amaraso adahagije mu by’ubutare, gishobora kumenya neza amatsinda afite ibyago byinshi, kigatanga ishingiro ryizewe ryo gusuzuma no kuvura neza nyuma yaho, kandi gifite akamaro gakomeye mu buvuzi no mu mibereho myiza mu guteza imbere impinduka mu gukumira no kuvura amaraso adahagije no kugera ku gusuzuma no kuvura hakiri kare.

Amagambo y'ingenzi: isesengura rya hemoglobine; gusuzuma amaraso make; Spectrophotometry; Konsung H7; Ubuhanga bwo gusuzuma

Intangiriro

Anemia ni indwara iterwa n’urugero rwa hemoglobine (HB) ruri munsi y’ibisanzwe, aho umubare w’abantu ku isi ugera kuri 24.8%, aho kubura icyuma (fer anemia) bingana na 50%. Anemia y’igihe kirekire ntabwo itera gusa intege nke z’ubudahangarwa bw’umubiri no kudakora neza mu bwenge, ahubwo ishobora no gutera indwara z’umutima n’imitsi, cyane cyane zitera indwara

Akaga gakomeye ku matsinda yihariye nk'abagore batwite n'abana. Ariko, gupima bisanzwe, bishingiye ku gupima amaraso buri gihe kandi bigasaba ibikoresho binini byikora, bifite ibibazo nko kugura ibikoresho byinshi, gukora ibintu bigoye, no gupima igihe kirekire, bigatuma bigorana guhaza icyifuzo cyo gusuzuma vuba mu buvuzi bw'ibanze [1]. Konsung hemoglobin analyzer (H7 series) yagiye ikundwa buhoro buhoro mu gupima amaraso mu bigo by'ubuvuzi by'ibanze bitewe n'uburyo bwo kuyipima no kuyipima vuba (igihe cyo kuyipima ≤ amasegonda 3). Iyi mashini ikoresha spectrophotometric igezweho kugira ngo inyuze mu mbogamizi za tekiniki zo gupima bisanzwe. Ishobora kubona neza amaraso make yakusanyijwe mu rutoki, ikongera cyane imikorere yo gupima no kubahiriza amategeko y'umurwayi. Iyi ngingo isuzuma ku buryo burambuye imikorere y'igikoresho n'agaciro kacyo mu buvuzi, igamije gutanga ishingiro rya siyansi ryo kunoza gahunda zo gupima amaraso no guteza imbere ubuvuzi bushingiye ku nzego zitandukanye, no gufasha gukemura ikibazo cy'ibura ry'ibikoresho by'ubuvuzi ku rwego rw'ibanze.

Ibiranga tekiniki bya Konsung hemoglobin analyzer

Ingingo ngenderwaho yo gushakisha n'ibipimo by'ingenzi

Icyo gikoresho, gishingiye ku ihame rya spectrophotometer, gipima ingano ya hemoglobin mu maraso yose hakoreshejwe uburyo bwa SLS-Hb, aho gishobora gupimwa hagati ya 0–250g/L n'ingano ya 1g/L [2]. Ibice byacyo by'ingenzi birimo microfluidic chip, urumuri rwa 532nm rw'uburebure n'ibice by'amashanyarazi, bipima ingano ya HB bipima agaciro k'urumuri rw'umuti nyuma yo gucibwa kwa hemolysis. Igenzura ry'ubuvuzi ryagaragaje isano ya 0.98 (P

Ibyiza n'imbogamizi mu mikorere

Ibyiza

1. Byihuse kandi byoroshye: Nta mpamvu yo kuvurwa mbere y’ingero zigoye, hakenewe 7μL gusa y’amaraso yo ku rutoki kugira ngo ikizamini kirangire, bigabanya 90% by’igihe cyo gukusanya ikizamini ugereranije n’ibizamini bisanzwe by’amaraso. Iki gikoresho gifite uburyo bworoshye kandi bwumvikana, kandi nyuma y’amahugurwa asanzwe, abakozi b’abaganga batari abanyamwuga bashobora kurangiza ikizamini mu munota umwe, bikongera cyane imikorere yo gusuzuma [3]. Urugero, mu gusuzuma abantu bageze mu za bukuru mu gace batuyemo, ingano y’ikizamini cya buri munsi ishobora kugera ku nshuro eshatu z’ibikoresho bisanzwe.
2. Uburyo bwo gukoresha neza ikiguzi: Igiciro cy'ibikoresho bikoreshwa mu isuzuma rimwe kiri hasi ho 30% ugereranyije n'ikizamini gisanzwe cy'amaraso, kandi ibikoresho biroroshye kubungabunga kandi ntibisaba gupima kenshi.
3. Uburyo bwo gukoresha: Iki gikoresho ni gito kandi gishobora kwimurwa, cyane cyane kibereye ahantu hadafite ubushobozi buhagije nko mu bigo bipimisha amaraso, mu bubiko bw'amaraso, mu modoka zitanga amaraso, no mu bitaro by'abaturage [4]. Mu buvuzi bw'ubuntu mu turere twa kure cyangwa mu gupima ubuzima bw'abakozi b'ibigo, uburyo kidakenera umuriro wo hanze (ufite bateri yo imbere imara amasaha arenga 8) gikemura neza ikibazo cy'ibikoresho gakondo bishingiye ku bidukikije bya laboratwari kandi giteza imbere kwagura serivisi zo gupima amaraso mu baturage no mu bigo bitwara abantu.

Guhuza amakuru

Ifite ubushobozi bwo kohereza amakuru hakoreshejwe Bluetooth, ihuzwa n'ububiko bw'amakuru bw'ubuvuzi bwo mu karere kugira ngo ihererekanywe amakuru mu buryo bwihuse. Abatanga serivisi z'ubuvuzi bw'ibanze bashobora kohereza vuba ibisubizo mu bitaro byo ku rwego rwo hejuru cyangwa ku mbuga nkoranyambaga z'ubuzima rusange, byorohereza gukora inyandiko z'ubuzima bw'abarwayi no gukurikirana ibintu mu buryo buhamye. Isesengura ry'amakuru manini rifasha inzego z'ubuzima kumenya imiterere y'amaraso mu karere kugira ngo ritange ingamba zo kwirinda [5].

Imbibi

1. Amakuru abura ku miterere y'umubiri: Kudashobora gutanga ibipimo by'ingenzi nk'ingano y'uturemangingo (MCV) n'ubugari bw'uturemangingo dutukura (RDW), bigira ingaruka ku kumenyekana kw'ubwoko bw'amaraso adahagije;
2. Ibintu bishobora kubangamira: Isuzuma ry’amaraso rya hyperbilirubinemia (> 20mg/dL) cyangwa chylous bishobora gutuma habaho ibisubizo bidafite aho bihuriye.

Iterambere rishya mu kugenzura hemoglobine igendanwa

Ikoranabuhanga rishya ryo kumenya neza

Hemoglobini ni poroteyine iboneka mu turemangingo dutukura tw’amaraso itwara umwuka uva mu bihaha ikawujyana mu bindi bice by’umubiri. Ni ingenzi ku buzima bw’umuntu. Hemoglobini iri hasi ishobora kugaragaza ko umuntu afite indwara zimwe na zimwe, harimo aplastic anemia, kanseri, indwara zidakira z’impyiko, na cirrhosis, bityo kugenzura hemoglobin mu buryo bwihuse ni ngombwa. Konsung H7 series portable hemoglobin analyzer ikoresha ikoranabuhanga rya microfluidic, spectrophotometry, na scattering compensation kugira ngo hamenyekane neza ko ari ukuri kw’ubuvuzi (CV ≤ 1.5%) [6–8]. 7μL gusa y’amaraso yo ku rutoki ikeneye gukusanywa, kandi ibisubizo by’ibizamini bizagaragara ku ibara rya TFT mu masegonda 3. Kubika ibisubizo by’ibizamini 2.000 bitanga uburyo bworoshye bwo kugenzura urugero rwa hemoglobin mu buzima bwa buri munsi.

Hakoreshejwe uburyo bwizewe bwa hemoglobine hamwe n'uburyo bwo gupima bukoreshwa neza, Hb na HCT bishobora kumenyekana vuba kandi neza kugira ngo bipime kandi bikurikirane indwara nka anemia, polycythemia, indwara ya sickle cell, nibindi [9–11]. Ikoreshwa cyane mu maraso kandi ishobora no gukoreshwa mu buvuzi, mu bipimo byo kuryama, muri laboratwari z'ubuvuzi, mu bitaro, nibindi.

Isesengura ry'ikoreshwa ry'ubuvuzi

1. Gusuzuma mu buryo bunini: Mu bipimo 5.000 byakorewe mu bigo by’ubuvuzi bw’ibanze, igikoresho cyagaragaje igipimo cyiza cya 12.3% (abantu 616) bafite ikibazo cyo kubura amaraso, ibyo bikaba byari bihuye na 91.8% by’ibyavuye mu isuzuma ry’amaraso ryakurikiyeho;
2. Gukurikirana ibintu mu buryo buhamye: Gukurikirana uburyo bwo kuvura abarwayi bafite ikibazo cyo kubura amaraso mu byuma byagaragaje ko impinduka zagaragaye muri HB zijyanye n’uko ibimenyetso by’uburwayi byazamutse (r = 0.79, P
3. Ibikwiriye abantu runaka: Ku barwayi b'abana (imyaka 3-12), nta kubogama gushingiye ku myaka kwagaragaye mu ikosa ry'ikizamini (P = 0.45), ariko hakwiye kwitabwaho ingaruka z'ubufatanye bw'abana mu gihe cyo gufata amaraso.

Ubwiyongere n'uburyo ibintu byihariye

Hitamo ingero 800 z'amaraso yo kwa muganga (harimo ingero 220 z'abagabo, ingero 300 z'abagore, n'ingero 280 z'abana) [12]. Ibizamini bikorerwa ubu kuri BC-5140 automatic blood cell analyzer yakozwe na Mindray Bio-Medical Electronics Co., LTD. (izwi hano "BC-5140") hanyuma kuri Konsung H7-3 hemoglobin analyzer (izwi hano "H7-3"), kandi ibisubizo by'ibizamini byombi byasesenguwe mu mibare kandi habarwa ubushishozi n'umwihariko wa H7-3 hemoglobin analyzer [13]. Imbonerahamwe ya 1 igaragaza ibyavuye mu kizamini cyakorewe ku bagabo. Hakoreshejwe aya makuru, ubushishozi n'umwihariko byarabazwe, ari byo 96.70% na 94.74%, uko bikurikirana.

Imbonerahamwe ya 1. Amakuru y'ibizamini by'abagabo

Ubushobozi bwo kwiyumvisha ibintu = 176 / (176 + 6) × 100% = 96.70%

Ubwihariye = 36 / (36 + 2) × 100% = 94.74%

Imbonerahamwe ya 2 igaragaza ibyavuye mu isuzuma ryakorewe ku bipimo by’abagore. Hakoreshejwe aya makuru, hakozwe ubushakashatsi ku bushishozi n’uburyo bw’isuzuma ry’icyorezo, ari byo 96.80% na 92.00% uko bikurikirana.

Imbonerahamwe ya 2. Amakuru y'ibizamini by'abagore

Ubushobozi bwo kwiyumvisha ibintu = 242 / (242 + 8) × 100% = 96.80%

Ubwihariye = 46 / (46 + 4) × 100% = 92.00%

Imbonerahamwe ya 3 igaragaza ibisubizo by'ikizamini cyakorewe ku bipimo byafashwe ku bana. Hakoreshejwe aya makuru, hakozwe ubushakashatsi ku bushishozi n'uburyo bw'isuzumabumenyi, ari byo 98.33% na 85.00% uko bikurikirana.

Imbonerahamwe ya 3. Amakuru y'ibizamini by'abana

Ubushobozi bwo kwiyumvisha ibintu = 236 / (236+4) × 100% = 98.33%

Ubwihariye = 34 / (34 + 6) × 100% = 85.00%

Imbonerahamwe ya 4 igaragaza ibyavuye mu bushakashatsi bwose. Ubuhanga n'ubushobozi bw'isesengura rya hemoglobine ya Konsung H7-3 byari 97.32%, naho umwihariko ukaba 90.63%.

Imbonerahamwe ya 4. Amakuru yose y'ibizamini

Ubushobozi bwo kwiyumvisha ibintu = 654 / (654+18) × 100% = 97.32%

Ubwihariye = 116 / (116+12) × 100% = 90.63%

Ibisubizo byo kugenzura ubuziranenge

Konsung itanga gahunda yuzuye yo kugenzura ubuziranenge igamije kugenzura no kugenzura ukuri kw'ibisubizo byakozwe n'icyuma gipima hemoglobine ya H7. Iyi gahunda ikubiyemo:

1. Uburyo bwo kugenzura ubuziranenge bwa hemoglobine: HBC-3A (Urwego rwa L, M, H)
2. Chipu yo kugenzura ubuziranenge bwa Hemoglobin analyzer: HBQC-3C (Ifite Chipu nyinshi, Ifite Chipu hagati, Ifite Chipu ntoya).

Kugereranya n'ubundi buryo bwo gutahura

Uburyo bwa mikorosikopi

Uburyo bwa mikorosikopi butuma umuntu amenya imiterere idasanzwe y’uturemangingo dutukura tw’amaraso, nk’uturemangingo twibandwaho. Ariko, bifata igihe kinini, akenshi bigatwara iminota irenga 15 kuri buri gipimo, kandi ukuri kwabwo guterwa cyane n’ubuhanga n’uburambe bw’umukoresha.

Isesengura ryikora ryikora ryikora ku buryo bwikora

Imashini zisesengura amaraso zikora mu buryo bwikora zitanga isesengura ry’ibipimo by’uturemangingo tw’amaraso mu buryo bunonosoye cyane. Nyamara, igiciro cyazo kiri hejuru, kuva ku nshuro 20 kugeza kuri 50 ugereranyije n’ikoreshwa ry’ibikoresho bya Konsung, gishobora kuba imbogamizi mu ikoreshwa ryabyo rikwirakwira.

Igikoresho cy'ibara ry'amashanyarazi gitwara imiziki

Ibi bikoresho bigendanwa bigaragaza imikorere imeze nk'iya Konsung H7 hemoglobin analyzer. Ariko, kugeza mu 2025, nta cyemezo cyatanzwe n'Ikigo cy'Igihugu gishinzwe Ibikoresho by'Ubuvuzi (NMPA), gishobora kubangamira

Kwemererwa kwa muganga no kwemezwa n'amategeko.

Ibitekerezo byo kunoza imikorere n'ibiteganijwe mu gihe kizaza

Iterambere ry'ikoranabuhanga

Uburyo bwo kumenya amashusho ya AI buhuriweho mu gusesengura imiterere y’uturemangingo dutukura tw’amaraso hakoreshejwe mikorosikopi yo hanze [14]. Muri iki gihe, AI yagaragaje ubushobozi bukomeye mu bijyanye no gusesengura amashusho y’ubuvuzi. Kuyishyira mu bikoresho bipima hemoglobine bishobora kugaragaza ingano n’imiterere idasanzwe y’uturemangingo dutukura tw’amaraso, bigafasha abaganga kumenya vuba ibimenyetso by’indwara nko kubura amaraso mu byuma no kubura amaraso mu buryo bwa megaloblastic. Ugereranyije n’isuzuma risanzwe rya mikorosikopi, AI ishobora kugabanya cyane amakosa y’umuntu ku giti cye, kunoza imikorere n’ukuri mu gusuzuma, kandi ikwiriye cyane cyane mu bihe aho uburambe bw’ibanze mu buvuzi budahagije.

Ibizamini byinshi by'index

Ibizamini nka serum ferritin na transferrin saturation bitanga ubumenyi bw'ingirakamaro ku bubiko bw'icyuma n'uko icyuma gihagaze, bigatuma habaho itandukaniro rigaragara hagati y'ubwoko butandukanye bwa anemia. Kwishingikiriza gusa ku gipimo cya hemoglobine akenshi ntibihagije, kuko bidatandukanya impamvu nko kubura icyuma, indwara zidakira, cyangwa izindi ndwara z'amaraso [15]. Mu kwagura ibipimo by'ibipimo, inkunga y'amakuru menshi yo gusuzuma anemia ishobora gukorwa, bigafasha abaganga kumenya vuba impamvu no gutegura gahunda z'ubuvuzi bwihariye. Ibi ntibizanoza urwego rw'ubuvuzi bw'ibanze gusa, ahubwo bizanagabanya umuvuduko w'abarwayi boherezwa mu bitaro no kunoza ikoreshwa ry'ibikoresho by'ubuvuzi.

Umwanzuro

Isesengura rya Konsung hemoglobin rigaragaza inyungu nziza kandi zihendutse mu gusuzuma amaraso make ku nshuro ya mbere kandi rishobora kuba igikoresho cyiza cyane mu buvuzi bw'ibanze. Hari ikibazo cy'ibikoresho byo gupima amaraso make n'abatekinisiye b'inzobere mu bigo by'ubuvuzi by'ibanze. Ibikoresho gakondo byo gupima amaraso make ntabwo bigoye gusa kubikoresha, ahubwo bifite n'ibikenewe cyane ku bidukikije no ku bakozi, bigatuma bigorana gukora akazi ko gupima vuba. Isesengura rya Konsung hemoglobin rikoresha uburyo bworoshye bwo gukusanya amaraso ku rutoki, ntirisaba ingero zigoye mbere yo kuvurwa, kandi rishobora gukoreshwa vuba n'abakozi b'abaganga nyuma y'amahugurwa yoroshye, bigabanya cyane uburyo bwo gupima no kunoza cyane imikorere yo gupima. Mu bukungu, ikiguzi cy'ibikoresho n'ibikoresho byo gupima ni gito cyane ugereranyije n'ibikoresho bisanzwe byo gupima, bishobora kugabanya neza umutwaro w'amafaranga ku bigo by'ubuvuzi by'ibanze. Byongeye kandi, igikoresho ni gito kandi gishobora kwimurwa, kandi gishobora gukoreshwa mu buryo bworoshye mu kuvura indwara za buri munsi, gusuzuma indwara zigendanwa mu turere twa kure, no gusuzuma ubuzima bw'abaturage, gutanga igisubizo gifatika cyo gusuzuma amaraso make ku nshuro ya mbere ku rwego rw'ibanze no gufasha kunoza urwego rwo kwirinda amaraso make no kuvura ku rwego rw'ibanze.

Itangazo ry'imenyekanisha

Umwanditsi avuga ko nta makimbirane y'inyungu afite.

Amareferensi

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Inyandiko y'umwanditsi

Who publishing ikomeje kutabogama ku bijyanye n'ibirego by'ububasha mu makarita yasohotse n'ibigo bifitanye isano.