Vanessa Chen

Jiangsu Konsung Bio-Ubuvuzi Ubuhanga n'Ikoranabuhanga Co, Ltd Nanjing 210012, Jiangsu, Ubushinwa

Ibisobanuro: Anemia, indwara yiganje cyane ku isi, igira ingaruka zikomeye ku buzima no ku mibereho y’abantu miliyoni amagana. Kwipimisha hakiri kare bifite akamaro kanini mugutezimbere abarwayi no kugabanya umutwaro windwara. Hamwe nubushobozi bwubuvuzi burohama murwego rwo hasi, birihutirwa guteza imbere ibikoresho bisuzumwa neza kandi byoroshye. Iyi ngingo ifata isesengura rya Konsung Hemoglobin (H7 ikurikirana) nkikintu cyubushakashatsi kandi igacengera mu gaciro kerekana ihame ryayo rya spekitifotometometrike yo gupima amaraso. Binyuze mu isesengura risesuye ryibipimo byerekana ibikoresho, amakuru menshi yo kwemeza ivuriro, no kugereranya nuburyo gakondo bwo gupima laboratoire, byagaragaye ko igikoresho cyerekanaga neza (± 2% intera ikosa) hamwe nubushobozi buhanitse (amasegonda 3 / sample) mukumenya umubare wa hemoglobine. Igishushanyo cyacyo cyimikorere nuburyo bworoshye bwo gukora byagabanije cyane urwego rwabakozi bambere babuvuzi babukoresha. Birakwiriye cyane cyane kwipimisha nini mubigo byubuvuzi byibanze. Ubushakashatsi bwerekanye kandi ko igikoresho gifite igipimo cyambere cyo gusuzuma 92.3% cyo kubura amaraso make, gishobora kumenya neza amatsinda afite ibyago byinshi, bigatanga urufatiro rwizewe rwo gusuzuma no kuvura neza, kandi bifite agaciro gakomeye k’ubuvuzi n’imibereho mu guteza imbere ihinduka ry’imbere yo gukumira no kuvura amaraso no kugera ku gusuzuma no kuvura hakiri kare.

Ijambo ryibanze: Isesengura rya Hemoglobin; Kwipimisha amaraso make; Spectrophotometry; Konsung H7; Gusuzuma neza

Intangiriro

Anemia ni syndrome de clinique ya hémoglobine (HB) iri munsi yubusanzwe, aho isi yose yiganje hafi 24.8%, muribo kubura amaraso kubura 50%. Amaraso maremare ntabwo atera gusa ubudahangarwa bw'umubiri no kwangirika kwimikorere yubwenge, ariko birashobora no gutera indwara zifata umutima nimiyoboro yubwonko, cyane cyane bitera a

iterabwoba rikomeye ku matsinda yihariye nk'abagore batwite n'abana. Nyamara, kwisuzumisha gakondo, bishingiye ku gupima amaraso bisanzwe kandi bisaba ibikoresho binini byikora, bifite ibibazo nkigiciro cyibikoresho byinshi, imikorere igoye, hamwe nigihe kinini cyo kwipimisha, bigatuma bigorana kubona icyifuzo cyo kwisuzumisha byihuse mubuvuzi bwibanze [1]. Isesengura rya Konsung hemoglobin (H7 series) ryagiye rimenyekana buhoro buhoro mugupima amaraso make mubigo byubuvuzi byambere bitewe nuburyo bworoshye kandi bwihuse bwo kumenya (igihe cyo kumenya amasegonda 3). Igikoresho gikoresha spropropotometometrike igezweho kugirango icike icyuho cya tekiniki yo gutahura gakondo. Irashobora gushishoza neza hamwe namaraso make yakusanyirijwe kurutoki, bikanoza cyane imikorere yo gusuzuma no kubahiriza abarwayi. Iyi ngingo isuzuma buri gihe uburyo bwo kumenya neza igikoresho nigiciro cyacyo cyo kwa muganga, kigamije gutanga ishingiro ryubumenyi bwogutezimbere gahunda yo gusuzuma anemia no guteza imbere ubuvuzi bukurikirana, no gufasha gukemura ikibazo cy’ibura ry’ibikoresho by’ubuvuzi ku rwego rw’ibanze.

Ibiranga tekiniki biranga Konsung hemoglobin isesengura

Ihame ryo gutahura nibintu byingenzi

Igikoresho, gishingiye ku ihame rya spekitifotometero, gipima ubunini bwa hemoglobine mu byitegererezo by'amaraso yose hakoreshejwe uburyo bwa SLS-Hb, hamwe no kumenya 0-2250g / L hamwe no gukemura 1g / L [2]. Ibigize ibice byingenzi birimo chip ya microfluidic, 532nm yumucyo wumucyo wumucyo hamwe na sensor ya foto ya elegitoronike, ibara ibirimo HB mugupima agaciro kinjira mumucyo nyuma ya hemolysis. Iyemezwa rya Clinical ryerekanye isano ya 0,98 (P.

Ibyiza byo gukora no kugarukira

Ibyiza

1. Byihuse kandi byoroshye: Ntibikenewe ko umuntu yitwara neza, hakenewe 7μL gusa yamaraso yintoki kugirango arangize ikizamini, azigama 90% yigihe cyo gukusanya icyitegererezo ugereranije nibizamini bisanzwe byamaraso. Igikoresho gifite interineti yoroshye kandi yimbitse, kandi nyuma y amahugurwa asanzwe, abakozi b’ubuvuzi badafite umwuga barashobora kurangiza ikizamini cyikitegererezo mu munota umwe, bikazamura cyane imikorere yo gusuzuma [3]. Kurugero, mugupimisha kumubiri kubantu bageze mu zabukuru mubaturage, ingano yikizamini cya buri munsi irashobora kugera inshuro eshatu kubikoresho gakondo.
2. Ikiguzi-cyiza: Igiciro cyibikoreshwa mugupimisha rimwe kiri munsi ya 30% ugereranije nikizamini gisanzwe cyamaraso, kandi ibikoresho biroroshye kubungabunga kandi ntibisaba kalibrasi kenshi.
3. Ibisabwa: Igikoresho kiroroshye kandi kigendanwa, cyane cyane kibereye ibintu bifite amikoro make nk'ibigo bisuzuma umubiri, amabanki y'amaraso, imodoka zitanga amaraso, n'ibitaro by'abaturage [4]. Mu bujyanama bw’ubuvuzi ku buntu mu turere twa kure cyangwa kwipimisha ku buzima ku bakozi b’ibigo, uburyo bwabwo bwo kudasaba amashanyarazi yo hanze (hamwe na bateri y'imbere imara amasaha arenga 8) ikemura neza ikibazo cy’ibikoresho gakondo bishingiye ku bidukikije bya laboratoire kandi bigateza imbere serivisi zipimisha amaraso make mu nzego z’ibanze no kuri terefone zigendanwa.

Guhuza amakuru

Ifite ubushobozi bwo kohereza Bluetooth, ihuza hamwe nububiko bwubuvuzi bwo mukarere kugirango dusangire amakuru nyayo. Abatanga ubuvuzi bwibanze barashobora kohereza ibisubizo byihuse mubitaro byo murwego rwohejuru cyangwa urubuga rwubuzima rusange, byorohereza ibyanditswe byubuzima bw’abarwayi no gukurikirana imbaraga. Isesengura rinini ryamakuru rifasha abayobozi bashinzwe ubuzima kumenya uburyo bwo kubura amaraso mu karere kugirango bamenyeshe ingamba zigamije gukumira [5].

Imipaka

1. Amakuru ya Morphologiya yabuze: Kudashobora gutanga ibipimo byingenzi nkubunini bwa selile (MCV) nubugari bwakagari gatukura (RDW), bigira ingaruka kumiterere yubwoko bwa anemia;
2. Impamvu zibangamira: Hyperbilirubinemia (> 20mg / dL) cyangwa urugero rwamaraso ya chylous bishobora gutera ibisubizo bibogamye.

Iterambere rishya mugukurikirana Hemoglobine

Ubuhanga bushya bwo gutahura neza

Hemoglobine ni molekile ya poroteyine iboneka mu ngirabuzimafatizo zitukura zitwara ogisijeni mu bihaha ikajya mu bindi bice by'umubiri. Ni ngombwa mubuzima bwabantu. Urwego rwo hasi rwa hemoglobine rushobora kwerekana ko umuntu afite indwara zimwe na zimwe, zirimo anemia aplastique, kanseri, indwara zimpyiko zidakira, na cirrhose, bityo rero hakenewe gukurikirana igihe nyacyo cya hemoglobine. Isesengura rya Konsung H7 isesengura hemoglobine isesengura ikoresha microfluidic, spectrophotometrie, hamwe nogukwirakwiza tekinoroji yindishyi kugirango hubahirizwe amavuriro (CV ≤ 1.5%) [6-8]. 7μL gusa yamaraso yintoki agomba gukusanywa, kandi ibisubizo byikizamini bizerekanwa kuri ecran ya TFT mugihe cyamasegonda 3. Kubika ibisubizo 2000 byikizamini bitanga uburyo bworoshye bwo gukurikirana urugero rwa hemoglobine mubuzima bwa buri munsi.

Ukoresheje uburyo bwizewe bwa hemoglobine hamwe nuburyo bukoreshwa bwo gutoranya, Hb na HCT birashobora gutahurwa vuba kandi neza kugirango bamenye kandi bakurikirane indwara nka anemia, polycythemia, indwara zifata umuhoro, nibindi [9-11]. Ikoreshwa cyane muri sitasiyo yamaraso kandi irashobora no gukoreshwa mubuvuzi, gupima ibitanda, laboratoire zubuvuzi, ibitaro, nibindi.

Isesengura ryibikorwa byo kwa muganga

1. Isuzumabumenyi rinini: Mu bizamini 5.000 byakorewe mu bigo nderabuzima by’ibanze, igikoresho cyagaragaje igipimo cyiza cya 12.3% (616) by’amaraso make, ibyo bikaba byari byemeranijweho na 91.8% by’ibisubizo by’amaraso byakurikiyeho byo kwisuzumisha;
2. Igenzura rikomeye: Gukurikirana uburyo bwo kuvura ibyuma byongera abarwayi bafite ikibazo cyo kubura amaraso make byagaragaje ko impinduka zahindutse muri HB zagaragaye zijyanye no kunoza ibimenyetso by’amavuriro (r = 0,79, P.
3. Bikwiranye nabantu runaka: Kubana barwayi (imyaka 3 - 12), nta kubogama gushingiye kumyaka byagaragaye mubibazo byikizamini (P. = 0.45), ariko hakwiye kwitabwaho ingaruka zubufatanye bwabana mugihe cyo gukusanya amaraso.

Ibyiyumvo byihariye

Hitamo icyitegererezo cy'amaraso 800 (harimo 220 by'abagabo, 300 b'abagore, na 280 by'abana). Ibizamini bikorerwa ubu kuri BC-5140 isesengura ryamaraso yikora yakozwe na Mindray Bio-Medical Electronics Co., LTD. . Imbonerahamwe 1 irerekana ibisubizo byikizamini cyakozwe ku ngero zabagabo. Ukoresheje aya makuru, ibyiyumvo byihariye kandi byihariye byabazwe, ni 96,70% na 94,74%.

Imbonerahamwe 1. Amakuru yikizamini cyabagabo

Ibyiyumvo = 176 / (176 + 6) × 100% = 96,70%

Umwihariko = 36 / (36 + 2) × 100% = 94,74%

Imbonerahamwe 2 yerekana ibisubizo by'ikizamini cyakozwe ku ngero z'abagore. Ukoresheje aya makuru, ibyiyumvo byihariye nibisobanuro byabazwe, ni 96.80% na 92.00%.

Imbonerahamwe 2. Amakuru yikizamini cyumugore

Ibyiyumvo = 242 / (242 + 8) × 100% = 96.80%

Umwihariko = 46 / (46 + 4) × 100% = 92.00%

Imbonerahamwe 3 yerekana ibisubizo by'ikizamini cyakozwe ku ngero zafashwe ku bana. Ukoresheje aya makuru, ibyiyumvo byihariye nibisobanuro byabazwe, ni 98.33% na 85.00%.

Imbonerahamwe 3. Abana bapima amakuru

Ibyiyumvo = 236 / (236 + 4) × 100% = 98.33%

Umwihariko = 34 / (34 + 6) × 100% = 85.00%

Imbonerahamwe 4 yerekana ibisubizo byamakuru yose yikizamini. Ibyiyumvo byihariye kandi byihariye bya Konsung H7-3 isesengura hemoglobine yari 97.32%, naho umwihariko ni 90.63%.

Imbonerahamwe 4. Amakuru yikizamini cyose

Ibyiyumvo = 654 / (654 + 18) × 100% = 97.32%

Umwihariko = 116 / (116 + 12) × 100% = 90,63%

Ibisubizo byubuziranenge

Konsung itanga gahunda yuzuye yo kugenzura ubuziranenge yagenewe gukurikirana no kugenzura niba ibisubizo by'ibizamini byakozwe na H7 hemoglobine. Iyi gahunda ikubiyemo:

1. Igisubizo cyo kugenzura ubuziranenge bwa Hemoglobine: HBC-3A (Urwego L, M, H)
2. Isesengura rya Hemoglobin igenzura ubuziranenge: HBQC-3C (Chip-hejuru, Chip-hagati, Chip-hasi).

Gereranya nubundi buryo bwo kumenya

Uburyo bwa Microscopique

Uburyo bwa microscopique butuma hamenyekana imiterere idasanzwe ya selile itukura, nka selile selile. Nyamara, biratwara igihe, mubisanzwe bisaba iminota irenga 15 kuri sample, kandi ubunyangamugayo bwayo bushingiye cyane kubuhanga nuburambe.

Isesengura ryikora ryuzuye

Isesengura ryuzuye rya hematologiya ryisesengura ritanga isesengura ryuzuye ryamaraso hamwe nibisobanuro bihanitse. Nubwo bimeze bityo ariko, igiciro cyinshi, kiri hagati yikubye inshuro 20 kugeza kuri 50 kurenza ibikoresho bya Konsung, birashobora kuba imbogamizi yo gukoreshwa henshi.

Igikoresho kigendanwa cyamafoto yamashanyarazi

Ibikoresho byimukanwa byerekana imikorere igereranywa na Konsung H7 hemoglobin isesengura. Ariko, guhera 2025, ntibabura ibyemezo byikigo cyigihugu gishinzwe ubuvuzi (NMPA), gishobora kubabuza

kwakirwa kwa muganga no kwemeza amabwiriza.

Ibyifuzo byo gutezimbere hamwe nigihe kizaza

Kuzamura ikoranabuhanga

Module yo kumenyekanisha amashusho ya AI kugirango igabanye igice cya kabiri cyo gusesengura amaraso atukura ya selile itukura ihuza microscope yo hanze [14]. Kugeza ubu, AI yerekanye imbaraga nyinshi mubijyanye no gusesengura amashusho yubuvuzi. Kwinjiza mubisesengura rya hemoglobine birashobora guhita byerekana ubunini budasanzwe nuburyo imiterere ya selile itukura, bigafasha abaganga kumenya vuba ibimenyetso biranga indwara nka anemia yo kubura fer na anemiya ya megaloblastique. Ugereranije nisuzuma rya microscopique gakondo, AI irashobora kugabanya cyane amakosa yibintu, kunoza imikorere yo gusuzuma no kumenya neza, kandi irakwiriye cyane cyane mubihe aho ubuvuzi bwibanze budahagije.

Ibizamini byinshi

Ibizamini nka serumu ferritine hamwe no kwiyuzuza kwa transferi bitanga ubumenyi bwingenzi mububiko bwicyuma no gutwara ibintu, bigafasha gutandukanya neza hagati yubwoko butandukanye bwa anemia. Kwishingikiriza gusa ku kizamini cya hemoglobine akenshi ntibihagije, kubera ko bidatandukanya impamvu zitera nko kubura fer, indwara zidakira, cyangwa izindi ndwara z’amaraso [15]. Mu kwagura ibipimo byipimisha, hashobora gushirwaho amakuru menshi yamakuru yo gupima amaraso make, agafasha abaganga kumenya vuba icyabiteye no gutegura gahunda yo kuvura yihariye. Ibi ntabwo bizamura urwego rwubuvuzi bwibanze gusa, ahubwo bizanagabanya umuvuduko wo kohereza abarwayi no kunoza itangwa ryubuvuzi.

Umwanzuro

Isesengura rya Konsung hemoglobin ryerekana ibyiza kandi byubukungu mugupima kwambere kwa anemia kandi birashobora kuba igikoresho cyatoranijwe mubuvuzi bwibanze. Muri rusange harabura ibikoresho byo gupima hamwe nabatekinisiye babigize umwuga mubigo byubuvuzi bwibanze. Ibikoresho gakondo byo gupima amaraso make ntabwo bigoye gukora gusa, ahubwo bifite n'ibisabwa cyane kubidukikije n'abakozi, kuburyo bigoye gukora imirimo yo gusuzuma vuba. Isesengura rya Konsung hemoglobin, ariko, ikoresha uburyo bworoshye bwo gukusanya amaraso, ntisaba kwipimisha bigoye, kandi irashobora gukoreshwa vuba nabakozi bo kwa muganga nyuma yimyitozo yoroshye, bigabanya cyane inzira yo kwipimisha kandi bikazamura cyane imikorere yo gusuzuma. Mu bukungu, igiciro cyibikoresho nibikoreshwa ni gito cyane ugereranije n’ibikoresho gakondo bipimisha, bishobora kugabanya neza umutwaro w’amafaranga ku bigo by’ubuvuzi byibanze. Byongeye kandi, igikoresho kiroroshye kandi kigendanwa, kandi gishobora guhuzwa neza na serivisi z’ubuvuzi bwa buri munsi, kwipimisha kuri terefone mu turere twa kure, ndetse no kwisuzumisha ku buzima bw’abaturage, bigatanga igisubizo gifatika cyo gusuzuma ibipimo ngari byambere byo gupima amaraso make ku nzego z'ibanze no gufasha kuzamura urwego rwo gukumira no kuvura amaraso mu nzego z'ibanze.

Itangazo

Umwanditsi atangaza ko nta makimbirane y'inyungu.

Reba

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